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Stewart M, Burris JF "Rebound hypertension during initiation of transdermal clonidine." Drug Intell Clin Pharm 22 (1988 573-4.
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Hodge RH, Harward MP, West MS, et al "Sexual function of women taking antihypertensive agents: a comparative study." J Gen Intern Med 6 (1991 290-4.Backo AL, Clause SL, Triller DM, Gibbs KA "Clonidine-induced hypertension in multiple regression excel two independent variables a patient with a spinal lesion." Ann Pharmacother 36 (2002.Ref Psychiatric Psychiatric side effects have included emotional disorder (5 aggression (1 tearfulness (3) and rare reports of depression, which has been the most common psychiatric reaction to clonidine.Sinus node arrest, junctional bradycardia, high degree AV block, and arrhythmias palpitations, Raynaud's phenomenon, syncope, and tachycardia."Allergic skin reactions to transdermal clonidine." Lancet 2 (1983 850-1.Puskas F, Camporesi EM, O'Leary CE, Hauser M, Nasrallah FV "Intrathecal clonidine and severe hypotension after cardiopulmonary bypass." Anesth Analg 97 (2003.Byrd BF, Collins HW, Primm RK "Risk factors for severe bradycardia during oral clonidine therapy for hypertension." Arch Intern Med 148 (1988.Pettinger WA "Clonidine, a new antihypertensive drug." N Engl J Med 293 (1975.The proposed mechanism is predominance of clonidine's peripheral alpha-1 adrenergic effects due to the patient's autonomic dysfunction, resulting in vasoconstriction and hypertension.Doe N, Seth S, Hebert LA "Skin depigmentation related to transdermal clonidine therapy." Arch Intern Med 155 (1995 2129.Ref A study of 13 patients who had pre - and post-clonidine cerebral blood flow (CBF) measured by nuclear scanning revealed that patients with an initially high pretreatment CBF tended to demonstrate decreased CBF after clonidine therapy.Patients with preexisting sinus auto receive email outlook 2007 node dysfunction, patients who have developed bradycardia while taking other sympatholytic agents, patients who are on another sympatholytic agent, and patients with renal dysfunction are at increased risk of clonidine-associated sinus bradycardia.Filos KS, Patroni O, Goudas LC, Bosas O, Kassaras A, Gartaganis S "A dose-response study of orally administered clonidine as premedication in the elderly - evaluating hemodynamic safety." Anesth Analg 77 (1993.Golusinski LL, Blount BW "Clonidine-induced bradycardia." J Fam Pract 41 (1995.Dick JB, Northridge DB, Lawson AA "Skin reactions to long-term transdermal clonidine." Lancet 1 (1987 516.Ref Genitourinary Genitourinary side effects have included impotence in male patients (24 retrograde and delayed ejaculation, and an inability to achieve orgasm in female patients.Rare, anxiety blistering, burning, crusting, dryness, or flaking of the skin chest pain or discomfort confusion as to time, place, or person decreased urine output dilated neck veins drowsiness dry mouth fast, pounding, or irregular heartbeat or pulse fever general mass effect 2 installation feeling of discomfort or illness.
Maloney MJ, Schwam SJ "Clonidine and sudden death." Pediatrics 96 (1995.
The signs and symptoms of diabetes and the nephrotic syndrome disappeared within five months after discontinuation of clonidine.